Pyrantel Pyrantel instructions for use

Composed of drug in tablets contains active ingredient pyrantelas well as additional components: methyl parahydroxybenzoate, gelatin, acacia gum, starch, sodium carboxymethyl starch, talc, magnesium stearate, propyl parahydroxybenzoate, colloidal silicon dioxide.

Suspension Pirantel contains the active component of pyrantel, as well as additional components: sucrose, xanthan gum, sorbic acid, polysorbate 80, methyl parahydroxybenzoate, solution sorbitol 70%, propyl parahydroxybenzoate, flavors, purified water.

Release form

Is produced suspension and pyrantel tablets.

Suspension is a homogeneous yellow mass. Contained in dark glass bottles of 15 ml.

Flat-cylindrical tablets with a facet, on the one hand - risk. Yellow pills. A polymer can can have 3 or 6 tablets.

Pyrantel how to take the drug for children and adults

Pyrantel is a simple and long-known medicine based on the active substance of the same name, used in case of ascariasis, hookworm, enterobiosis. An anthelmintic drug has a mild effect on the body, acts instantly, is approved for use by children and adults.

How to take an adult and what properties does it have?

Despite a century of innovative technology, a scientific breakthrough, about 21 million people on the planet suffer from parasitism of helminths. The pharmaceutical industry is developing new drugs to destroy worms and worms in the human body, but there are old time-tested drugs that are trusted by parasitologists, infectious disease specialists and their patients.

A vivid example of this is Pyrantel from worms, which is used for treatment and as a preventive measure.

Drug action

Pyrantel is active against roundworms (nematodes). The most common ones are:

  • roundworm,
  • pinworms
  • whipworms that enter the intestines with poor-quality food.

The action of the drug paralyzes adult and immature worms of both sexes, preventing their movement and reproduction. Immobilized parasites leave the body naturally through bowel movements: taking an additional medication with a laxative effect is not required.

Pyrantel does not have the ability to neutralize helminth larvae and does not destroy egg laying. In connection with this feature of the drug after a course of treatment, the instructions for use recommend re-deworming. This will eliminate the remaining helminth larvae already in their puberty phase.

Often, anthelmintic courses are not recommended. The maximum content of the drug in the patient’s blood is reached three hours after administration.

Pharmacotherapeutic group:

ATX Code: P02CC01.

Pharmacological properties
Pyrantela pamoat is an anthelmintic drug with a wide spectrum of action. The mechanism of action is associated with the blocking of neuromuscular conduction in helminths. Active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma doudenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis. It acts on both sexually mature and immature individuals of both sexes, does not affect larvae in the migration stage.

Pharmacokinetics
After oral administration, pyrantel is poorly absorbed from the digestive tract. After taking a single dose of 10 mg / kg body weight, the concentration of pyrantel in the plasma is 0.005-0.13 μg / ml for 1-3 hours. The pyrantel absorbed into the systemic circulation is partially metabolized in the liver to N-methyl-1,3- propanediamine. 50% of the dose taken is excreted unchanged with feces, about 7% - with urine unchanged or as a metabolite.

Indications for use
The main indications for use are ascariasis, hookworm infection, necatorosis and enterobiasis.

Contraindications
- Myasthenia gravis (treatment period),
- Children's age up to 3 years (solid dosage form),
- Hypersensitivity to pyrantel and other components of the drug.

Carefully
Liver failure.
Pregnancy and lactation
In pregnancy, it is used only if the intended benefit to the mother outweighs the risk to the fetus. When used during lactation, it is recommended to stop breastfeeding.

Dosage and administration
The drug is prescribed orally during or after meals and the dosage is set individually depending on the age and body weight of the patient.
Ascaridosis and enterobiosis, as well as mixed invasions - once at a dose of 10 mg / kg body weight.

AgeDose of the drug
Children 3 years - 6 years old250 mg (1 tab.)
Children 6 years old - 12 years old500 mg (2 tablets)
Children over 12 years old and adults with m750 mg (3 tablets)
Adults with m> 75 kg1000 mg (4 tablets)

Chew the tablet carefully.
Hookworm: the drug is prescribed at the rate of 10 mg / kg body weight per day for 3 days.
Necatorosis: in severe forms, the drug is prescribed in a dose of 20 mg / kg body weight per day for 2 days.

Side effect
From the gastrointestinal tract and liver: decreased appetite, nausea, vomiting, diarrhea, stomach pain are possible, rarely - increased activity of hepatic transaminases.
From the side of the central nervous system: rarely - headache, dizziness, drowsiness, insomnia, weakness, in some cases - hearing impairment, hallucinations, confusion, paresthesia.
Other: skin rash, fever.

Overdose
Treatment: gastric lavage. There is no specific antidote.

Interaction
Do not use concomitantly with piperazine (weakening effect).
With the simultaneous use of pyrantel increases the concentration of theophylline in plasma.

special instructions
After taking pyrantel, a laxative is not prescribed.
With enterobiosis, simultaneous treatment of all cohabiting individuals should be carried out. After completion of treatment, it is necessary to conduct a control study of feces for the presence of parasite eggs.
Careful hygiene is necessary (cleaning of premises and cleaning of clothes to destroy helminth eggs serves as prevention of reinfection).

Release form
250 mg tablets
3 tablets per strip of aluminum foil or in a blister of PVC / aluminum foil.
1 strip or 1 blister is placed in a cardboard box along with instructions for use.

Storage conditions
In a dry, dark place at a temperature of no higher than 25 o C.
Keep out of the reach of children.

Shelf life
3 years. Do not use an expired drug.

Pharmacy Vacation Terms
On prescription.

Description of the drug and price

Since not only adults, but also young children need medical treatment, Pirantel is released not only in tablet form, but also in the form of a suspension. Pirantel tablets, the cost of which ranges from 12 to 60 rubles, released even without a doctor’s prescription, for suspension in a pharmacy a buyer will have to pay a price of 28-75 rubles. Based on how much Pirantel costs, it becomes clear why it is so often used in the fight against parasitic infections.

To determine how to take such a drug can only be the attending doctor, for this they are preliminarily tested, and the diagnosis is clarified. Pyrantel acts on the neuromuscular transmission of helminth impulses in any form and stage of development. If the patient has migratory larvae, here the components of Pyrantel will be powerless. Very often, this medication is used as a prevention of worms.

When asked how to drink Pirantel, doctors give recommendations:

  • children from 6 months to 3 years old should take a suspension,
  • Children 3 years old Adult patients may take pills.

Due to the fact that the drug has low adsorption, it is the safest and less toxic when compared with other antiparasitic agents. Due to the impossibility of an overdose, Pirantel is prescribed for children of the youngest age. If for some reason the dosages have been exceeded, it is better for a person to rinse the stomach.

The main component of this medicine is pyrantelpamoate.that answers the question of how Pirantel works. It blocks the transmission of nerve impulses of the worms, which leads to their paralysis. Thanks to this, helminths can no longer linger in internal organs and leave the human body without causing intoxication from the decay of dead individuals.

Appointment Cases

Since the anthelmintic drug has a directed effect on a certain type of helminths, treatment with Pirantel is prescribed in the following cases:

  • the presence of pinworms in the body (enterobiosis) - the most common disease among children,
  • infection with geohelminths-hookworms (hookworms) - the disease develops only in people,
  • Ascaris damage (ascaridosis) - the infection progresses mainly in a warm climate,
  • flatworm infection with nekator (nekatorosis) - infection occurs through the skin,
  • whipworm infestation (trichocephalosis) - helminths are very active in the human body.

You can use Pirantel to prevent parasitic diseases in case of contact with the object of infection. If suspected of helminthic invasion, it is necessary to take tests. The doctor will determine the degree of the disease and prescribe the appropriate dose of medication. Self-administration of Pirantel is excluded.

Appearance and composition

In pharmacies, Pyrantel tablets of yellow tint are sold in 3-6 pieces per pack, suspension is a yellow substance with a viscous consistency of 15 ml in a bottle. In liquid form, Pirantel can also be used by adults.

The active ingredient - pyrantel, coincides with the name of the drug. As additional ingredients, the instructions for use declares:

  • corn starch,
  • gelatin,
  • flavor enhancer sodium starch gluconate,
  • emulsifier E572 (magnesium stearic acid),
  • talc.

The liquid version is supplemented with chocolate essence and drinking water.

Instructions for use of the suspension

The dosage of Pirantel is calculated in proportion to the body weight and age of the patient. When infected with ascariasis and enterobiasis, the dose of active pyrantel taken is 1 mg weight - 10 mg. The medicine is prescribed for children from six months of age. For convenient dosing, a 5 ml measurement is attached to the bottle with the drug.

How to drink the suspension, according to the age category and body weight, see table:

AgeAmount of liquid in measuring spoons
Six months - three years1/2
From 3 to 6 years1
6 to 12 years old1½ – 2
Teenagers from 12 years old and adults weighing up to 75 kg3
People weighing more than 75 kg4

Before applying the suspension, the bottle must be shaken to shake the liquid. If the doctor has not prescribed an individual dosage regimen, Pirantel is drunk once a day. The reception time is chosen at any convenient: in the morning or in the evening.

The tablet version of the drug is prescribed more often for adults, but in the absence of a suspension, the medicine in the form of tablets is also given to children. If the child has not previously taken the medicine in tablets, it will be appropriate to crush the required dose into powder and dissolve in a small amount of water. Use the medicine once a day, observing the indicated dosage.

Directions for taking Pirantel in tablets:

  • infants up to 3 years - ½ tablets,
  • up to 6 years - one tablet,
  • up to 12 - two tablets,
  • adults and adolescents after 12 years take 3 tablets at once,
  • patients whose weight is more than 75 kg, to achieve the desired effect, it is necessary to take at least 1000 mg (4 tablets) for a single dose.

General recommendations on how to take Pirantel correctly:

  1. The time of taking the drug has nothing to do with eating. You can take anthelmintics both before meals and after.
  2. For maximum effect, drink Pirantel again after 21 days.
  3. It is better to take the drug at night.
  4. With the advanced stage of parasitic invasion, the dose is doubled. How many days in this case to take Pirantel should be decided by the attending physician.
  5. The drug is not prescribed to infants until six months.
  6. During the treatment period, one should not overload the diet with heavy food.
  7. If one member of the family is infected, prevention of helminthiasis is necessary for everyone else.

Pharmacodynamics and pharmacokinetics

In order to defeat helminthiasis disease, it is necessary to correctly select drugs, paying due attention to the pharmacodynamics and pharmacokinetics of the drug. When the drug begins to act, parasites in the human body will block the neuromuscular transmission of impulses, as is usually the case with depolarizing muscle relaxants.

All this causes helminth paralysis, which will last exactly as long as it takes to remove them from the body. This action the drug provides against several types of parasites - roundworms and pinworms, hookworms. Also, indications may be such diagnoses as hookworm, trichocephalosis, enterobiosis, necatorosis. The substance will give a result in the fight against sexually mature individuals and their offspring.

It is better to take the drug in the evening, so that the elimination of parasites begins in the morning. The drug is not absorbed in the digestive organs, the effect of the drug begins after 1-3 hours, pyrantel pamoat will act until partial excretion with urine and feces. It is also better to give the drug to the child in the evening, so that the helminths begin to die during his sleep.

Special instructions for the use of the drug

Instructions for the use of an anthelmintic drug contain instructions for safe use and a warning about side effects. It is forbidden to conduct anthelmintic events by Pirantel:

  • children up to six months
  • people with liver pathologies
  • in the presence of autoimmune disorders.

During pregnancy, taking the drug is unacceptable in the first trimester. At later dates, Pirantel can be taken, but with caution and under the strict supervision of a doctor. When breastfeeding, the use of the drug is allowed only with the condition that the child is stopped feeding.

Warning: during treatment with Pirantel it is not allowed to consume alcohol-containing drinks. A small enough dose is taken so that alcohol provokes an exacerbation of adverse side effects.

When undergoing treatment, it is undesirable to drive vehicles in connection with possible manifestations of instability of the nervous system.

Side effects from taking the drug include:

  • from the central nervous system: dull pain in the temples, often dizziness, malfunction of the biological clock,
  • general weakness, malaise,
  • from the digestive system: vomiting, pain in the stomach and intestines, upset stool,

  • the manifestation of allergic reactions from the epidermis,
  • malfunction of the gallbladder and liver,

The amount of active Pyrantel should not exceed the dose prescribed by the doctor. In case of unintentional overdose of the drug, you should rinse your stomach, if necessary, call an ambulance.

The drug is not used in conjunction with other anthelmintic drugs, in particular with Levamisole and Piperazine, in order to prevent intoxication of the body.

Prevention of helminthic infestations by Pyrantel is recommended twice a year, during the off-season. In kindergartens and schools, preventive measures are taken in case of infection in one or more children.

Indications for use

Not every type of helminthiasis involves treatment with just such a drug, so before choosing ways to solve problems, you need to familiarize yourself with the indications for the use of Pyrantel.

  • Pirantel can neutralize pinworms with a single dose, 90% of patients with helminthiasis today suffer from enterobiasis,
  • in case of roundworm infection after taking the pill, all individuals leave the body,
  • infection of the circulatory system as a result of hookworm infection can be treated with Pirantel,
  • necatorosis is characterized by the presence of tenacious parasites that can neutralize Pirantel,
  • this medication is able to stop the causative agents of toxocariasis.

If the patient has one of the above diagnoses after diagnosis and consultation with a specialist, you can start treatment with such a drug.

Pharmacological properties

Pharmacokinetics

It is poorly absorbed in the gastrointestinal tract. The plasma concentration of the drug after taking a single dose of 10 mg / kg body weight is 0.05 - 0.13 μg / ml for 1 to 3 hours.

Data on the penetration of the drug through the placenta and into breast milk, as well as the location of the drug in biological tissues and fluids, are absent (theoretically, absorption of the drug is minimal).

The minimum amount of the drug absorbed in the gastrointestinal tract is partially metabolized in the liver to N-methyl-1,3-propanediamine (0.8-5.6%).

Excretion

More than 50% of the dose taken orally is excreted unchanged with feces and less than 15% with urine unchanged or as a metabolite of N-methyl-1,3-propanediamine.

Pharmacodynamics

Pyrantel is an effective drug for infection with intestinal roundworms. It acts on the muscles of intestinal nematodes by depolarizing their neuromuscular junction and blocking the action of cholinesterase. Immovable parasites are eliminated from the intestines due to peristaltic movements. Does not cause helminth migration, does not have an irritating effect. It acts on mature forms and on parasites at an early stage of development and does not affect larvae during their migration in tissues. The drug is used primarily for infections with pinworms (Enterobius vermicularis) and roundworms (Ascaris lumbricoides).

It can be used for infection with hookworm, has a more effective effect in the treatment of hookworm than in the treatment of necatorosis.

Pyrantel tablets: instruction for use

To get the desired result, the tablet must be thoroughly chewed or crushed. The dosage calculation is carried out in proportion to the person’s body weight, and the treatment regimen takes into account the diagnosis:

  • for enterobiosis, ascariasis, mixed invasion, 750 mg of Pyrantel with a body weight of 75 kg is taken once (these are three tablets), if the body weight is more than 75 kg, 1000 mg of the component is taken (these are 4 tablets),
  • in the case of a diagnosis of hookworm, the patient takes the same dosage, but within 3 days.

Dosage and administration

The drug is taken orally, during or after a meal, washed down with water.

Before swallowing, the tablet should be chewed or ground thoroughly.

For diseases caused by Ascarislumbricoides,Enterobiusvermicularis,AncylostomaduodenaleandNecatoramericanus, depending on the age and body weight of the patient, the following doses are recommended:

How to take a suspension of Pirantel?

In this case, the patient’s age, type of helminthiasis, and body weight are also taken into account. For each kilogram, 10 mg of suspension is taken, the medicine is taken once. If a person weighs less than 75 kg, he is prescribed 15 ml of suspension (dose 0.75 g). Adult patients who weigh more than 75 kg take 20 ml (dose 1 g). With hookworm, the suspension is taken within 3 days.

If the patient has a severe form of the disease, intense invasion, most often Pirantel's administration is extended by 3 days.

Breastfeeding Pyrantel

In medical practice, it is forbidden to take anthelmintic drugs during the period of bearing a child, more precisely in the 1st trimester, as well as during breastfeeding. This is due to the risks of negative effects on the child, but judging by animal experiments, Pirantel did not adversely affect the fetus and newborn body.

Due to the fact that during the treatment with Pirantel it shows a low ability to be absorbed from the gastrointestinal tract, the risks of side effects are minimal, therefore, doctors are more likely to take a positive decision regarding taking Pirantel during pregnancy and lactation.

But on the other hand, during the period of gestation, a woman suggests an increased likelihood of reactions of the body to external stimuli and factors, as well as to medications. In addition, a pronounced hormonal background during pregnancy can accompany the manifestation of side effects.

Since the drug is taken either once or within 3 days, for this period of time it is better to stop breastfeeding, but subject to its subsequent recovery. 3 hours after taking the pill, you can feed the babya. Before you start taking the pills, you need to discuss this issue with the gynecologist, it is this doctor who will be able to find the safest and most effective dosage.

During pregnancy

Like any antibiotic or potent drug, antiparasitic drugs are contraindicated in women during gestation or breastfeeding. But due to the fact that the mechanism of action of Pirantel, its low toxicity, the ability to simultaneously treat and prevent helminthiasis even in children, is a reason for the doctor’s reasoning.

If the medical specialist does not see significant contraindications, the drug can be used when absolutely necessary by a pregnant woman or during lactation. How the action of the drug will occur should also be observed by the doctor to prevent risks.

Pyrantel for prevention

In the presence of pets in the house or visiting a child of a preschool or school institution, the drug Pirantel is taken in order to prevent helminth infestations. In this case, it is very important to consult a doctor to get the desired results and not provoke the development of side effects.

The dosage of Pyrantel for prophylaxis for adults is calculated according to body weight, 10 mg of the component is taken for each kilogram. You can take the drug at any time of the day. But usually the doctor recommends taking the pill in the morning. Treatment with Pyrantel does not require the use of laxatives, this will only reduce the results of therapy.

Contraindications and side effects

When it comes to tablets, Pirantel is taken by patients older than 3 years. For small patients, a suspension is assumed, and only the attending physician decides how many days to take Pirantel and how to take such a medicine correctly.

The following categories of the population are prohibited:

  • people with individual intolerance to the components of the drug,
  • pregnancy at 1 trimester,
  • women during lactation,
  • Hypersensitive individuals
  • people who have hypertension
  • in the case of tachycardia and angina in humans.

In case of pregnancy, taking Pirantel is possible only with the permission of the gynecologist. If you do not adhere to contraindications, Pirantel medicine may cause the following side effects:

  • skin rash,
  • recurrent headaches
  • fever
  • nausea and vomiting
  • pain in the stomach
  • bowel disorder
  • some liver dysfunction,
  • insomnia,
  • breakdown and weakness.

Very rarely, in the event of an overdose, a person may experience hallucinations and confusion, hearing loss, and also paresthesia.

The subtleties of treatment

Like other medications, Pirantel has a number of treatment features. For example, a single dose will not always be sufficient for recovery, so the question is how many days to take Pirantel in one case or another. If the patient has pinworms, all other family members need to take such a medication. To prevent the risks of self-infection with pinworms again, which is so typical of enterobiosis, I repeat the administration of Pirantel after 20 days.

The tablet should be taken in the morning, it is chewed thoroughly and washed down with plenty of water. Treatment does not require additional intake of laxatives. It is forbidden to take any other antiparasitic drugs during therapy. If for some reason it is impossible to take Pirantel, analogues are used - Combantrin, Nemocide or Helminthox.

Alcohol compatibility

The course of treatment with Pyrantel can be monthly or short-term in order to prevent re-infection. In any case, situations may arise when a person expects a holiday and the likelihood of drinking alcohol. What to do if you have to take a pill, is it worth it to start therapy, you need to consult a doctor.

Most often, taking alcohol and drugs at the same time can lead to the following consequences:

  • antagonism is a consequence of complete incompatibility,
  • poisoning,
  • low effectiveness of the drug against the background of interaction with alcohol,
  • increased side effects, especially if it is alcoholism and the use of the drug.

The manufacturer clarifies that during clinical trials there were no cases of incompatibility of the drug and alcoholic beverages. Therefore, the development of side effects should not occur, but the effectiveness of therapy may decrease, which means that Pirantel will not help and work against parasites, whether it be a small or large tape helminth.

Pirantel: consumer reviews

We have a small child in our family who picked up worms in a manger. They underwent treatment with the whole family, the doctor prescribed a suspension for the child, and the parents took the pill once. An excellent drug, it did not cause any side effects, after conducting several tests, the presence of parasites was not detected. Three weeks later, they took a prophylactic dose, as recommended by the infectious disease specialist.

Before buying Pirantel, I studied all the reviews about it on the Internet and on forms. Not a single negative response has become a decisive factor. Ascaris was found in me, after which the doctor offered treatment with such a drug. I agreed, moreover, a single dose made the treatment process quick and elementary. Analyzes were performed three times, and all three times the presence of parasites was not established. Therefore, for me this is the best drug.

Our daughter was infected with parasites at school, after which the doctor advised me to use the Pirantel suspension. They took the right dose, after a while the dose was repeated for prophylaxis. No side effects were noticed, the child was active and did not complain about anything. At a young age, she was treated with another antiparasitic drug (I do not remember the name), which caused indigestion and nausea.

Suspension for children

Since in young children the internal organs and the immune system have not yet had time to get stronger, doctors often use drugs in the form of suspensions, emulsions or syrups in treatment. The same applies to Pirantel, who is so in demand for the treatment of small patients. It is children who most often suffer from parasitic worms because of their carelessness and love for animals.

Dosage of the suspension for children according to age:

  • children from 6 months to 2 years old take 2.5 ml of suspension (half a scoop)
  • children from 2 to 6 years old - 5 ml of suspension (full measuring spoon),
  • children from 6 to 12 years old - 10 ml of the product (two measuring spoons),
  • for adolescents over 12 years old, we can take 15 ml of suspension (3 scoops),
  • if body weight exceeds 75 kg, take 20 ml of suspension (4 scoops).

Pyrantel is effective against roundworms in a child (roundworms, hookworms, pinworms), but only after diagnosis, diagnosis and calculation of a safe dose by a doctor. A single dose is taken in the morning, and after 20 days the course can be repeated in order to prevent re-infection. In addition to medical treatment, it is important to strengthen sanitation and personal hygiene.

Frequently Asked Questions

Before starting therapy or prevention from helminthiases (giardiasis, ascariasis, nematodosis, etc.), you should find out the purpose of the drug, as well as get all the answers to questions. For this, the manufacturer and medical specialists give preliminary answers to the most relevant topics. Early instruction on them will allow you to correctly use Pirantel without harm to health.

If your stomach hurts after Pirantel, is this normal?

Since all medications pass through the gastrointestinal tract, and anthelmintics also have toxicity, diarrhea, diarrhea, nausea, abdominal pain, feeling sick, dizzy, and other dyspeptic symptoms may occur. Since the components of the tablets will begin to kill helminths, all this can manifest itself with signs of intoxication.

In addition, the drug can cause temporary reactions of the pancreas, gall bladder, showing characteristic symptoms. A dead helminth can thin out decay products, which is extremely negatively perceived by the body. Therefore, minor pain disappears over time, if the pain syndrome is increasing in nature, it is important to see a doctor.

How long does it take to act?

Before taking the drug, it is important to check its validity, since tablets that have expired may not give a result at all, in addition, a side effect may occur. All this is bad for the course of the disease, plus, if it is a late effect, helminthiasis has every chance of increasing the scale. Therefore, it is important to choose a fresh preparation, the expiration of which is not yet close. The active component begins to act on parasites 1-3 hours after ingestion.

How to take Pirantel for adults?

Given that the drug is available in different forms, instructions for use and dosage are set forth separately for each of them.

As for convenience, everything is individual here: experts suggest that it is better for small children to give Pirantel in the form of an emulsion, and from 3-5 years you can already take pills.

Each of the options is easy to choose a specific dose, initially 1 tablet contains 250 mg of active substance. The same applies to 5 ml of emulsion.

  • The classic dosage of tablets for an adult in the presence of pinworms or roundworms is calculated by weight. Reception should be single, with the course usually being only 1-3 days.
  • For each kg of weight, 10 mg of the drug is taken. So, for example, with a weight of 80 kg, you need to take 800 mg of Pyrantel. This is 3 tablets means (3 measures of emulsion).
  • The tablets are necessarily chewed, or crushed before use and mixed with food. But basically they are taken after meals, in the morning (after breakfast).
  • During breastfeeding to receive Pirantel, the process is stopped, after the end of the reception, they resume after 1-2 days. This time will be enough so that the drug is completely eliminated from the body and not transmitted with milk.

Pharmachologic effect

Pyrantel is anthelmintica drug. In the body, it destroys worms or parasitic worms. It affects the muscles of intestinal parasites, which leads to the blocking of nerve endings in the muscles. It affects both the mature forms of parasites and worms and worms in the early phase of development. Under the influence of peristalsis, they are excreted in the feces. In this case, the larvae that pass through the tissue are not affected.

Pharmacokinetics

It is practically not absorbed in the digestive tract. After oral administration in a single dose of 10 mg / kg body weight Cmax is 0.005–0.13 μg / ml and is achieved within 1-3 hours. It is partially metabolized in the liver to N-methyl-1,3-propanediamine. It is excreted with feces (50% of the dose taken - unchanged) and with urine (about 7% - unchanged and as a metabolite).

Is it possible to give Pirantel to a cat if he has worms?

Kill parasites or prevent their appearance as a whole family. If only a child needed Pirantel syrup, it can be given to adult family members for prevention. If there are pets, they may also need to pack with the drug.In the case of taking Pirantel by a cat, you need to understand that this anthelmintic is not always able to completely destroy parasites, since some types of animal worms are not resistant to the active substance.

Side effects

In the process of treatment, the manifestation of such side effects is possible:

  • nervous system: drowsiness, headache, dizziness, insomnia,
  • digestive systemvomiting diarrhearecurrent abdominal cramps, anorexia, tenesmus,
  • skin and subcutaneous tissue: hivesrash
  • hepatobiliary system: increased liver enzymes,
  • other manifestations: feeling of weakness, increased fatigue.

Suspension Pirantel, instructions for use

Suspension for children is used according to indications, before taking it, you need to shake it. Patients with ascariasis and enterobiosis are prescribed an average dose of 10-12 mg per 1 kg of weight in one dose. Children after 6 months should receive syrup at a dose of 2.5 ml per 10 kg of weight in one go. Adult patients (up to 75 kg) receive 15 ml in 1 dose. If a person's weight exceeds 75 kg, in one step you need to drink 20 ml of the product.

To improve effectiveness in the treatment of enterobiasis, you should carefully follow all the rules of personal hygiene. Another course of therapy is recommended after three weeks.

Patients with ankylostomidosis in endemic areas or with severe invasion are prescribed a drug based on a dosage of 20 mg per 1 kg of weight for 2 or 3 doses, the treatment lasts 2-3 days.

The dosage per day is calculated as follows:

  • children after 6 months receive 5 ml of syrup per 10 kg of weight,
  • with a weight of up to 75 kg - 30 ml of syrup per day,
  • with a weight of 75 kg - 40 ml of syrup per day.

Subject to mild invasion Ankylostoma duodenale sometimes it is enough to take a dose of 10 mg per 1 kg once.

Pirantel tablets, instructions for use

Adults are usually prescribed Pirantel in tablets. It should be taken before or during the application of food. The tablet is chewed and washed down with a large amount of liquid.

How to take Pirantel for children depends on their body weight and age:

  • at the age of 2-6 years, 250 mg of the drug is indicated,
  • at the age of 6-12 years - 500 mg,
  • children after 12 years old and adult patients weighing up to 75 kg - 750 mg,
  • adults, whose weight exceeds 75 kg - 1000 mg.

If only infection with a human nematode is noted, Pyrantel 5 mg per 1 kg of weight should be taken in one ave.

For patients with enterobiasis and ascariasis, as well as with mixed invasions, the dose that is intended for the entire course is used once (10 mg per 1 kg).

Patients with hookworm infection are shown to take the same dose for three days.

In the case of massive invasions of Necator americanus, a dose of 20 mg / kg for two days is indicated

For more information about how many days to take the drug, how to drink tablets and suspension for adults and children for treatment, as well as for prevention for adults and children, you should ask your doctor.

Overdose

With an overdose of the drug, the patient may experience such negative manifestations: nausea, vomiting, diarrhea, anorexia. But it should be borne in mind that pyrantel is poorly absorbed in the body, which is why signs intoxication are very rare even with a significant overdose. If there is such a need, gastric lavage, specific antidote is absent. It is important to control the function of blood vessels, heart, respiratory system.

How many pinworms (and other parasites) die after taking the pill?

Each person's reaction to Pirantel tablets can be completely different. With someone, excretion of pinworms and other types of parasites can occur after 3-5 hours, someone will need a little more time. The effect of taking the remedy will occur quite soon, if you take the pills at night, the helminths die and you can completely leave the body by morning.

It all also depends on intestinal motility, clogged bowels, whether food was taken during the period of taking the tablets, what dose was used, and also due to the peculiarities of the digestive system. But the international standard says that during the night, Pirantel is able to completely destroy parasites.

Interaction

Do not prescribe treatment with Pirantel simultaneously with the use of Levamisole, since in this case, potentiation of the toxic effect of Levamisole may be noted, the level in the plasma also increases Theophylline.

Do not use tablets and suspension simultaneously with piperazine, since this drug is an antagonist of the anthelmintic effect of Pyrantel.

What if Pirantel didn’t help me?

As a rule, Pirantel shows high efficacy in the fight against certain types of parasites. The advantage of this drug is its low toxicity, which is why parasites do not always begin to die after its action, which means that the drug may not help. For a complete cure, the drug should be taken according to the instructions and the prescription of the doctor several times with interruptions, preventing re-infection.

If the drug does not help even under such conditions, the doctor may choose a potent analogue, even if it is harmful and toxic. The main objective of therapy is the elimination of helminth infections, even if unpleasant side effects occur. In addition, it is worth giving preference to anthelmintics with a wide profile of action. A good preparation can be drunk in one go so that the worms come out with the stool completely.

Where to buy Pirantel and how much does it cost?

Before taking Pirantel tablets or syrup, you need to take a scraping and other tests to find out the type of parasites, after which the doctor assesses how much Pirantel will be able to help in the treatment. You can buy a medication in any department of the pharmacy, difficulties with its search will not arise due to the wide availability of Pirantel.

The price is considered a plus of the drug - the cost of a package with three tablets will be from 24 to 37 rubles, depending on the manufacturer, and you will need to pay 32-34 rubles for a bottle with a suspension. The suspension begins to dissolve and act faster, and the effect may last longer from the tablets. After taking the drug, it is important to observe the stool, in which dead helminths should appear.

Caution!

With extreme caution, taking tablets or a suspension of Pirantel is necessary for serious liver diseases. Doctors are required to individually select the optimal dosage of the drug for each patient, in particular children. If gastritis, peptic ulcer of the digestive system, congenital anomalies are observed, therapy should be carried out under the supervision of a doctor.

Reviews on the Internet from patients, as well as recommendations from experts suggest that Pyrantel is considered the safest drug among all anthelmintics, it is most often advised to give it to children for prevention or control of worms. Signs of intoxication may occur from the side effects, but with the release of helminths, they pass by themselves.

1 comment on this article: Pyrantel tablets: instructions for use for adults

Pyrantel, a very good medicine to combat parasites in our body. As for me, I think that the drug is working, it affects each person in different ways. So you need to visit a doctor. Health to you!

Note to parents

Pirantel's intake in children is broken not by weight, but by age

It is important to know that babies under the age of 6 months. not allowed any of Pirantel's options, from 6 months

you can drink the emulsion, and from 3 years - tablets. Reception of any form is carried out during meals (experts advise doing this in the morning).

The emulsion for a child up to 2 years of age in dosage should not exceed 2.5 ml and can be reduced in premature babies and babies with reduced body weight.
A child aged 2 to 6 years is given 5 ml of Pyrantel once.
3-year-old child can start taking Pirantel tablets

Dosage - 1 tablet once.
A child over 6 years old can be given 10 ml of an emulsion, or 2 tablets.
After 12 years, the child approaches an adult dose: 15 ml of an emulsion or 3 tablets once.
Pay attention to the principle of using pills: in order to increase the effectiveness of therapy, they must be chewed carefully, and after taking an enema or an additional laxative. However, the gap between them should be 2 hours: this will contribute to the conclusion of the destroyed helminths.

What you need to know about taking Pirantel?

For prevention, Pirantel is very rarely drunk, since the drug has an active effect, and also often gives side effects that should not be caused unnecessarily. But if you are seriously tormented by the presence of parasites, you can use the following scheme:

Drink 5 mg per kg of net weight once, repeat intake after 21 days. It is equally effective in preventing pinworm infection and in preventing ascariasis.

In addition, it should be remembered that with increased sensitivity of the body, even the norm of the drug will be perceived as an overdose, which can cause side effects. To eliminate them, gastric lavage is used.

Possible reaction from the body to Pirantel: headache, nausea and vomiting, dyspepsia, weakness, dizziness, rash, fever.

Before you start taking Pirantel, you need to find out what parasites the infection occurred - it is possible that they do not fall under the spectrum of the drug. In addition, the drug is not recommended for people with liver failure.

When infected with helminths, it is necessary, along with taking medications, to carry out a general cleaning in the whole house with disinfectants, to wash and iron all linen, towels, bedding.

If you have pets, they must be treated for parasites, even if there is no apparent need for this, as a preventive measure

It is also important to remember that prevention is the best way to prevent helminth infections.

It includes careful observance of the rules of personal hygiene, both by adults and children.

How to take pyrantel in tablets for adults immediately Colds-no

Worms are one of the most common problems of mankind. Parasites lie in wait at every step, so that the problem can affect any of us.

According to studies around the world, about a quarter of the population are carriers of one kind or another of helminths.

Therefore, if we are not able to completely eliminate the risk of helminthiasis, we must understand how to deal with an unpleasant ailment.

Synonyms of nosological groups

Heading ICD-10The synonyms of diseases according to ICD-10
B76 hookwormHookworm
Intestinal infestation
B76.1 NecatorosisIntestinal infestation
B77 AscaridosisHelminthic invasion
Intestinal infestation
Ascarids intestinal invasion
Intestinal nematodes
B80 EnterobiasisHelminthic invasion
Pinworm
Intestinal infestation
Intestinal nematodes
Oxyuriaz
Oxyurosis

Effective anthelmintic drug Pirantel

In the pharmaceutical market, the choice of helminth-free drugs is incredibly large. Different medicines help to remove certain types of helminths. Among the entire list, Pirantel is considered one of the most famous drugs.

The drug is available in several forms:

  1. Suspension - in this form, Pirantel is advised to give children. The medicine has a sweetish aroma and unobtrusive taste.
  2. 250 mg tablets in a shell. In this form, the drug is intended for adults.

The drug is considered effective for necatorosis, ascariasis, enterobiasis. The active ingredients of the drug in any form help paralyze protozoa that have infected the body, as a result of which they are effectively excreted by the natural method, as they are not able to cling to the walls of the stomach.

How to take Pirantel - choose medications in tablets and suspensions

The dosage of the drug in the form of a suspension is usually calculated in accordance with the body weight of a person. For 1 kilogram, there should be 10 mg of active substance.

It’s easy to calculate the dose - 5 mg in a measuring cap has 250 grams of active substance. So for 10 kg of weight you need 4 tiny caps. But modern doctors use a similar scheme with a strong form of infection with worms.

In other cases, 1-2 caps are sufficient for children, depending on age.

Pills are just as easy. One tablet contains exactly as much active substance as a 5 mg cap.

But with a mild form of infection, it is better to take Pirantel in tablets correctly according to the following recommendations:

  1. Adults up to 75 kg are recommended to drink three tablets at a time or three capsules of the suspension.
  2. Adults who weigh more than 75 kilograms need to drink four tablets or four caps.

Pirantel's reception is not tied to the time of day. You can drink the drug at any time. But it is better to drink medicines during or immediately after a meal. The tablets are recommended to chew well and drink plenty of water.

How many days should I take Pirantel for adults?

The course of treatment depends on what form of helminthic invasion affects the body:

  • When diagnosing ascaris or pinworms, the drug is taken once. Moreover, it is imperative that the whole family is treated, since this type of helminthiasis is transmitted without problems.
  • If ascariasis is detected, after the first dose, the drug is taken again after 20 days. Dosage does not change. This eliminates the likelihood of reinfection.
  • With hookworm, the course of treatment is three days. The dose does not change.
  • Necatorosis and some other types of helminthic invasion require a doubling of the usual dose, and the course of treatment is already two days instead of one.

In addition to the rules of admission and dosage, you must adhere to the rules of personal hygiene, eat only clean products. Drinking Pyrantel in tablets is not recommended for adults with laxatives, they can reduce the effectiveness of Pyrantel on parasites.

Taking Pirantel and the negative consequences

The administration of an anthelmintic in tablets or suspension does not generally cause side effects.

But some negative manifestations may be noted:

  • Stool problems.
  • Temperature rise.
  • Rash.
  • Nausea and vomiting.
  • Renal failure with intolerance to the active substance of the drug in humans.

Such manifestations are rare. Since Pyrantel from the gastrointestinal tract hardly enters the bloodstream, its administration is easily tolerated.

This makes the anthelmintic drug an effective tool for the treatment of helminth infections in children, pregnant women and nursing mothers.

True, the latter is advised to stop breastfeeding during the treatment so that the active substance does not enter the baby’s body with mother’s milk.

Prevention of worms at the expense of drugs

Pyrantel is one of the few anthelmintic drugs that are chosen for the prevention of worms. Its mild effect on the body, the almost complete absence of side effects make it a very popular option for those who prefer to prevent infection with protozoa.

Pirantel's analogs

Analogues of this tool are drugs Nemocide, Helminthox, Pirantela Pamoatthat contain a similar active ingredient. Drugs have a similar effect on the body. Vermox, Biltricid, Wormin, Decaris and etc.

Prices in pharmacies in Moscow

Drug nameSeriesValid untilPrice for 1 unit.Price per pack, rub.Pharmacies
Pyrantel
tablets 250 mg, 3 pcs.
28.00 At the pharmacy 154725.00 At the pharmacy 28.00 At the pharmacy 15.00 At the pharmacy Pyrantel
tablets 250 mg, 3 pcs. 38.00 At the pharmacy 464939.00 At the pharmacy 38.00 At the pharmacy 23.00 At the pharmacy Pyrantel
suspension for oral administration 250 mg / 5 ml, 1 pc. 60.00 At the pharmacy 65.00 At the pharmacy 154833.00 At the pharmacy 26.00 At the pharmacy Pyrantel
suspension for oral administration 250 mg / 5 ml, 1 pc. 59.00 At the pharmacy 33.00 At the pharmacy Pyrantel
suspension for oral administration, 1 pc.
Poll

Current Information Demand Index, ‰

The opinion of "Doctors of the Russian Federation" about the drug Pirantel

  • Overall rating6.5(out of 10)
    Efficiency3.5(out of 5)
    Security3(out of 5)
    Details on the project and rating calculation methodology

Registered Vital and Essential Drugs

Pirantel registration certificates

  • P N014859 / 01
  • LP-000231
  • P N012326 / 01
  • LP-002914
  • P N012326 / 02
  • P N014090 / 01
  • P N013548 / 01
  • P N013548 / 02-2001
  • P N014609 / 01-2002
  • P N014609 / 02-2002
  • P N012326 / 01-2000

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Pyrantel for children

Reviews of Pirantel for children left by their parents are mostly positive. However, it should be borne in mind that the instruction for suspension for children provides that the drug is not prescribed for children under 3 years of age. It is important to strictly follow the instructions on how to take the suspension. The dosage for children should be carefully observed.

Reviews of Pirantel

Reviews of the Pirantel suspension for children on the network in most cases are positive. Both users and doctors agree that the suspension and tablets from worms allow you to quickly get rid of parasites, while not provoking the manifestation of negative effects. Reading the reviews of parasitologists, we can conclude that this drug is one of the most effective anthelmintic.

Pirantel's price, where to buy

The price of a suspension of Pyrantel 15 ml is, on average, 60 rubles. The cost may be slightly lower or higher. The price of Pyrantel tablets depends on the packaging and manufacturer. On average, buy a pack of 3 tablets. possible at a price of 20 to 40 rubles. How much does this drug cost in pharmacies, you should ask directly at points of sale.

Instructions for use of the drug

The use of Pyrantel is indicated for the treatment of:

  • ascariasis,
  • hookworm,
  • necatorosis
  • trichocephalosis.

Only the attending physician will tell you how to take Pirantel correctly, the instructions for use Pirantel recommends only approximate dosages. Pyrantel in tablets is taken:

  1. inside after eating
  2. tablets should be chewed, swallowed and only then washed down with water.

Important! The dosage of the drug depends on the type of helminthiasis, the massiveness of the lesion, the age and weight of the patient.

How to take Pyrantel in tablets for adults:

  1. with a weight of 75 kg. take 4 tablets once,
  2. patients weighing up to 75 kg - 3 tablets once.

Instructions for use for children:

  1. over 12 years old - 750 mg once (15 ml of suspension),
  2. 6-12 years - 500 mg once (10 ml),
  3. 3-6 years - 1 tablet or 250 mg (5 ml) once.

Pyrantel for young children is given based on weight: 10 mg per kg. If the baby weighs 15 kg, the medicine is taken at a dose of 125 mg.

Pyrantel suspension is taken as follows:

  • 6-24 months - 2.5 ml,
  • 2-6 years - 5 ml,
  • 6-12 years old - 10 ml,
  • from 12 years old with a weight of up to 75 kg - 15 ml.

For adult patients weighing more than 75 kg, 20 ml or more can be taken, depending on the massiveness of the invasion. How to take medicine depending on the type of disease:

  1. isolated ascariasis - 1 time per day,
  2. severe form of necatorosis - 1 time per day for 2 days,
  3. hookworm - a course of 3 days at a dosage prescribed by the attending physician.

Watch the video: Pinworms. How To Get Rid of Pinworms. Threadworms Treatment 2019 (April 2020).